Example

Our team’s research to date has yielded the following academic publications and presentations.

Publications

2018

  • Saccomanno, M., Hussain, S., O’Connor, N.K., Beier, P., Somlyay, M., Konrat, R., and Murphy, C.D., ‘Biodegradation of pentafluorosulfanyl-substituted aminophenol in Pseudomonas spp.‘, Biodegradation (in Press).

  • Rodil, A., Bosisio, S., Ayoup, M.S., Quinn, L., Cordes, D.B., Slawin, A.M., Murphy, C.D., Michel, J. and O'Hagan, D., 'Metabolism and hydrophilicity of the polarised ‘Janus face’all-cis tetrafluorocyclohexyl ring, a candidate motif for drug discovery'. Chemical Science, 9(11), pp.3023-3028.

  • Tomita, R., Al-Maharik, N., Rodil, A., Buehl, M. and O'Hagan, D., 'Synthesis of aryl a, a-difluoroethyl thioethers a novel structure motif in organic chemistry, and extending to aryl a, a-difluoro oxyethers'. Organic and Biomolecular Chemistry.

  • 2017

  • Lisse, E. and Sandford, G., 'Synthesis of β-fluoro (dicarbonyl) ethylamines from 2-fluoro-ethylacetoacetate and dimethyl-2-fluoromalonate ester by batch and semi-continuous flow three-component Mannich reactions' 'Journal of Fluorine Chemistry.

  • Sadurní, A., Kehr, G., Ahlqvist, M., Peilot Sjögren, H., Kankkonen, C., Knerr, L., and Gilmour, R., ‘Fluorine‐Directed Glycosylation Enables the Stereocontrolled Synthesis of Selective SGLT2 Inhibitors for Type II Diabetes‘, Chemistry-A European Journal (in Press).

  • Murphy, C.D., Palmer-Brown, W., Quinn, L., and Saccomanno, S., ‘Microbial metabolism of fluorinated drugs‘, Fluorine in Life Sciences, Pharmaceuticals, Medical Diagnostics and Agrochemicals. Eds G. Haufe and F. Leroux (in Press)

  • S. Voltrová, M. Muselli, J.Filgas, V.Matoušek, B.Klepetářová P.Beier, ‘Synthesis of tetrafluoroethylene- and tetrafluoroethyl-containing azides and their 1,3-dipolar cycloaddition as synthetic application‘, Org Biomol Chem 2017 DOI: 10.1039/c7ob01151b.

  • D. Gimenez, C.A. Mooney, A. Dose, G. Sandford, C.R. Coxon and S.L. Cobb, ‘The Application of Perfluoroheteroaromatic Reagents in the Preparation of Modified Peptide Systems‘, Org Biomol Chem 2017 DOI: 10.1039/C7OB00283A.

  • D. Gimenez, A. Dose, N.L. Robson, G. Sandford, S.L. Cobb and C.R. Coxon. ‘2,2,2-Trifluoroethanol as a Tool to Control Nucleophilic Peptide Arylation’. Org Biomol Chem 2017 DOI: 10.1039/C7OB00295E.

  • 2016

  • Vukelić, S., Moschner, J., Huhmann, S., Fernandes, R., Berger, A.A., and Koksch, B., 'Synthesis of side-chain fluorinated amino acids and their effects on the properties of peptides and proteins', in Modern Synthesis Processes and Reactivity of Fluorinated Compounds: Progress in Fluorine Science, 1st Ed., 2016 (in press).

  • Palmer-Brown, W., Dunne, B., Ortin, Y., Fox, M.A., Sandford, G., and Murphy, C.D., 'Biotransformation of fluorophenyl pyridine carboxylic acids by the model fungus Cunninghamella elegans.' Xenobiotica, 2016 (in press).

  • Blastik, Z. E., Voltrová, S., Matoušek, V., Jurásek, B., Manley, D. W., Klepetářová, B. and Beier, P. 'Azidoperfluoroalkanes: Synthesis and Application in Copper(I)-Catalyzed Azide–Alkyne Cycloaddition.' Angew. Chem. Int. Ed., (2016), doi:10.1002/anie.201609715.

  • Hampton, A.S., Mikulski, L., Palmer-Brown, W., Murphy, C.D., and Sandford, G., 'Evaluation of fluorinated biphenyl ether pro-drug scaffolds employing the chemical-microbial approach.' Bioorganic & medicinal chemistry letters 26, no. 9 (2016): 2255-2258.

  • Ajenjo, J., Greenhall, M., Zarantonello, C., and Beier, P., 'Synthesis and nucleophilic aromatic substitution of 3-fluoro-5-nitro-1-(pentafluorosulfanyl) benzene.' Beilstein journal of organic chemistry 12, no. 1 (2016): 192-197.

  • 2015

  • Murphy, C.D., and Sandford, G., 'Recent advances in fluorination techniques and their anticipated impact on drug metabolism and toxicity.' Expert opinion on drug metabolism & toxicology 11, no. 4 (2015): 589-599.

  • Murphy, C.D., and Sandford, G., 'Fluorinated pharmaceuticals: synthesis and opportunities.' European Biopharmaceutical Review (2015):72-74.

  • Presentations

    2017

  • Somlyay, M., ‘19F NMR spectroscopy applications in structural biology and drug development’, Austrian Chemistry Days, Salzburg, Austria, September 25-28, 2017 [Oral].

  • Lisse, E., ‘Synthesis and applications of fluorinated multi-carbonyl systems’, European Symposium on Organic Reactivity in Durham, UK, 3-8 September, 2017 [Poster].

  • Gimenez, D., ‘Stabilising α-Peptoid Helices Through Incorporation of Non-Chiral Fluoro-Alkyl Monomers’, 17th Annual RSC Fluorine Subject Group Postgraduate Meeting, Leicester, UK, September, 2017 [Oral].

  • Lisse, E., ‘Synthesis and applications of fluorinated multi-carbonyl systems’, 16th RSC Postgraduate Symposium in Fluorine Chemistry, Leicester, UK, September, 2017 [Oral].

  • Lisse, E., Melvin, A., Sandford, G., ‘Fluorinated dicarbonyl systems: chemical Swiss Army knives’, 18th Tetrahedron Symposium, Budapest, Hungary, 27th-30th June 2017 [Poster].

  • Gimenez, D., 'Exploring the Applications of Fluorine for Peptoid Structure Induction',Durham University Chemistry Postgraduate Gala Symposium. Durham. 15th June 2017.[Oral].

  • Lisse, E., ‘Synthesis and applications of fluorinated multi-carbonyl systems’, Durham Chemistry Postgraduate Gala Symposium, 15th June 2017 [Oral].

  • Lisse, E., Melvin, A., ‘Fluorinated dicarbonyl systems: chemical Swiss Army Knives’, RSC Organic Division North East Regional Meeting, Durham, 29th March 2017 [Poster].

  • Ajenjo, J., ‘Improving access to aromatic sulfur pentafluorides by direct fluorination of disulfides’, 23rd Winter Fluorine Conference, Clearwater Beach, Florida, USA, January 15th-20th, 2017 [Poster].

  • 2016

  • Palmer-Brown, W., ‘Microbial oxidation of fluorinated molecules to generate new pro-drug scaffolds’, CSCB symposium, RSCI, Dublin, Ireland, December 11th 2016 [Poster]

  • Somlyay, M., ‘19F NMR Spectroscopy Applications in Structural Biology and Drug Development’, Molecules of Life Vienna Doctoral School Retreat, Balaton, Hungary, September 29th-October 1st, 2016. [Oral]

  • Palmer-Brown, W., ‘Biotransformation of fluorophenyl pyridine carboxylic acids by the model fungus Cunninghamella elegans’, Biocat2016, Hamburg, Germany, August 28th- September 1st 2016 [Poster]

  • Ajenjo, J., ‘Synthesis and nucleophilic aromatic substitution of 3-fluoro-5-nitro-1-(pentafluorosulfanyl)benzene’, 5th International Symposium on Organofluorine Compounds in Biomedical, Materials and Agriculture Sciences (“Bremen Fluorine Days”), Bremen, Germany, July 3-7th, 2016. [Poster]

  • Gimenez, D., Dose, A., Sandford, G., Coxon. C.R., Cobb. S.L., ‘Perfluoro-heteroaromatic Tagged Oxytocin Analogs with Enhanced Enzymatic Stability’, 2016 RSC Organic Division North East Regional Meeting & Symposium, Newcastle. UK. April 6th, 2016. [Poster]

  • Fernandes, R., ´Fluorine in Peptide and Protein Engineering´, XV Iberian Peptide Meeting, Porto, Portugal, February 10th - 12th, 2016. [Oral]

  • Fernandes, R., ´Protein Engineering Through Fluorinated Amino Acids´, GRK 1582 Kollegseminar, Berlin, Germany, January 21st - 22nd, 2016. [Oral]

  • 2015

  • Gimenez, D., Dose, A., Sandford, G., Coxon, C.R., Cobb, S.L., ‘Perfluoro-heteroaromatic Tagged Oxytocin Analogs with Enhanced Enzymatic Stability’. Boulder Peptide Symposium . Colorado. US. September 28th – October1st, 2015. [Poster]

  • Dose, A., Gimenez, D., Sandford, G., Coxon, C.R., Cobb, S.L., ‘Novel Peptide Stapling and Cyclisation Using Perfluoro-heteroaromatics’, Boulder Peptide Symposium . Colorado. US. September 28th –October 1st, 2015. [Poster]

  • Murphy, C.D., 'Fungal biofilms and organfluorine compounds.', In 21st ISFC-ISoFT, Como, Italy, August 23rd-28th, 2015. [Oral]