Organofluorine chemistry has played a significant role in the majority of spectacular scientific and technological developments of the past century. Two key challenges in organofluorine chemistry remain; selective methods for the formation of carbon-fluorine bonds, and the synthesis of complex fluorinated molecules under mild conditions.

In this ITN, through a series of inter-connected work packages (WP4, WP5, WP6,), we will examine the preparation of complex fluorinated organic systems, and attempt to establish new stereoelectronic effects of fluorine atoms strategically placed within a new generation of polyfunctional systems.

Our early stage researchers will develop new selective fluorination processes by using new complementary chemoselective, chemo-enzymatic and biosynthetic methodology (WP4, WP6,). The Network will also explore the ability of the C-F bond to modulate the structural, physical and reactivity properties of organic systems (WP5). Additionally, the development of new selective fluorination methods (WP4,) coupled with the Network’s expertise in handling and analysing fluorinated molecules will allow us to extend the boundaries of what is possible in terms of engineering the properties of life science molecules through the strategic introduction of C-F bonds by molecular editing.