WP5

Applications of the C-F bond to control structure are very rare. The Network will harness the unique properties of the fluorine atom to modulate structure, reactivity and function in carbohydrates, peptides and peptoids. Such developments are highly relevant to the design of new drug entities (WP6).

Example

Project 5.1 Stereo-controlled coupling and ligation strategies in carbohydrate chemistry - ESR 5
Project 5.2 Tuneable protein design - ESR 6
Project 5.3 Structural control and rational design of peptoid architectures - ESR 2
Project 5.4 19F NMR evaluation of new fluorine probes (e.g. dynamic protein folding studies) - ESR 10, ESR 8